Overview:
ANTIBIOTIC AND ANTI-INFLAMMATORY INJECTABLE SUSPENSION OF AMOXICILLIN – 150.0 MG
Suspension of white-and-cream to light yellow colour.
COMPOSITION
• 1 ml of preparation contains the following active substances:
• Amoxicillin (as Amoxicillin Trihydrate) – 150.0 mg;
• Betamethasone (as Betamethasone Dipropionate) – 0.5 mg;
• Additional ingredients:
Benzyl Alcohol, Butylhydroxytoluene, Butylhydroxyanisole, Aluminum Stearate, Propylene Glycol Dicaprylate /Dicaprate.
PHARMACOLOGICAL PROPERTIES
* ATC vet code QJ01 – antibacterial veterinary preparations for systemic use. QJ01CA04 – Amoxicillin.
* Amoxicillin is an antibiotic with wide bactericidal action belonging to the group of Aminopenicillins. It blocks the synthesis of bacterial cell walls, and inhibits the enzymatic activity of Transpeptidase and Carboxypeptidase, causing the violations of osmotic pressure in bacterial cells that leads to the death of the bacteria at the stage of their growth. Preparation is active against Gram-positive and Gram-negative bacteria (Streptococcus spp., Pasteurella spp., Haemophilus spp., Bacillus anthracis, Actinomyces spp., Clostridium spp., Corynebacterium spp., Erysipelothrix Rhusiopathiae, Listeria Monocytogenes, Actinobacillus spp., Bordetella Bronchiseptica, Fusobacterium spp., Moraxella spp., Proteus Mirabilis, Salmonella spp.).
* A peak serum concentration is reached in 1-2 hours after the injection and remains on therapeutic levels within 48 hours.
* Amoxicillin is practically not metabolized. Excreted mainly in the Urine, less in Milk and Bile.
* Betamethasone belongs to the group of synthetic Corticosteroids (Adrenal hormones), it has anti-inflammatory, antipruritic, anti-allergic, and antiproliferative effects.
* Betamethasone Dipropionate has a prolonged effect due to slow absorption. Betamethasone bioavailability is approximately 72%, half-life is 5.6 hours, 64% of it binds to plasma protein.
* It is metabolized in the liver, and excreted by the Kidneys and only a small fraction is excreted in the bile.
ADMINISTRATION
Treatment of Cattle, Dogs and Cats in case of Digestive Tract diseases (Enteritis, Gastroenteritis, Gastroenterocolitis), Respiratory diseases (Bronchitis, Pneumonia, Rhinitis) and Urinogenital Tract diseases (Metritis, Endometritis, Mastitis, Agalactia, Cystitis, Urethritis, Pyelonephritis), in case of Joints, Skin and Soft Tissue diseases (Umbilical Infection, Wounds, Abscesses, Inflammation); and for the treatment of animals suffering from Leptospirosis, Actinomycosis, Parainfluenza, Paratyphoid, caused by pathogens susceptible to Amoxicillin.
ROUTE OF ADMINISTRATION AND DOSAGES
Intramuscularly or subcutaneously only once at a dose of 1 ml per 10 kg body weight. If necessary, the product is administered again in 48 hours.
CONTRAINDICATIONS
Do not administer to Rabbits, Guinea Pigs, Hamsters and other Rodents and to animals with hypersensitivity to Amoxicillin, Betamethasone or other drug ingredients.
Do not administer this product to pregnant Cows within the last month of pregnancy.
Do not administer to weak, emaciated animals and to animals with severe renal insufficiency.
Do not use it together with bacteriostatic antibiotics (Tetracycline, Chloramphenicol, Erythromycin, etc.).
PRECAUTIONS
Thoroughly shake before use.
Should not be injected more than 20 ml to Cattle, and more than 5 ml to Dogs in one site.
Not administered intravenously.
WITHDRAWAL PERIOD
For Meat: 42 days (Cattle) after last treatment. For Milk: 3 days after the last treatment. Meat and Milk received before this time should be disposed of or fed to non-producing animals, depending on the conclusion of the veterinarian.
STORAGE CONDITIONS
Store in a dry, dark place, out of the reach of children, at +5 to +25° С.
SHELF LIFE
24 months. After the first opening: 28 days if kept in a dry, dark place at +5 to +25° С.